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Airway Inflammation  LPS-induced acute lung inflammation in rodents Experimental allergic encephalomyelitis (EAE)  MBP induced acute EAE in Lewis rats  PLP139-151 induced EAE in SJL/J mice  MOG35-55 induced EAE in C57BL/6 mice Lung Fibrosis   Bleomycin induced lung fibrosis model in mice  Bleomycin induced mouse lung fibrosis model  Rheumatoid Arthritis  Adjuvant induced arthritis (AIA) in rats  Collagen type II induced arthritis (CIA) in rodents  Morphology Changes in rat CIA model. Normal joint (A) and joint with arthritis (B); inflammatory cell infiltration (C: macrophage (CD68); D: lymphocyte (CD3)).  Osteoarthritis (OA)  MIA induced OA i...
Acute renal injury modelIschemic reperfusion injury models in rodents  Acute rat renal ischemia reperfusion injury model. Ischemia time dependent changes in renal function  Acute unilateral ureteral obstruction model in rodents Unilateral ureteral obstruction model in rat showing interstitial accumulation ofmonocytes 3 days post-obstruction. Glomerulosclerosis, tubulointerstitial fibrosis andmetastatic calcification (about 4 months after model) Subacute / chronic renal failure models   Sub-total (5/6) nephrectomy model in rats  Sub-total renal infarction (1k nephrectomy with 1k 2/3 infarction) model in rats  Tubular toxic (adenine toxic) model in rats Long-Term Feeding of Adenine induces chronic renal failure model inrat showing inters...
Acute liver injury models  Alcohol induced acute liver injury in rodents  CCl4 induced acute liver injury in rodents  Liver ischemia reperfusion injury model in rodents   Alcohol induces acute liver injury showing hepatocyte degeneration, changes in serum TG and vLDL, liver tissue MDA, GSH and TG after alcoCCl4 induces an acute liver injury showing hepatocyte balloon injury with inflammatory cell infiltra-tion at dose of 0.5mg/kg, slight recovering from degeneration at 48hrs of CCl4 doing; much severe and wide hepatocyte balloon degeneration with remarkable inflammatory cell infiltration at dose of 1.0ml/kg. Severe hepatocyte necrosis with inflammatory cell infiltration appeared at 48hrs of doing. Serum AST, ALT and TG elevated significantly after C...
Obesity  High fat diet (HFD) induced obesity mice (DIO mice)  ob/ob mice, db/db mice  HFD induced DIO Rats  HFD induced mouse obesity at C57BL/6 male mice Diabetes  HFD (60% kcal)-induced DIO mice with diabetes  ob/ob, db/db mice with diabetes Diabetic Complication  Diabetic nephropathy in db/db mice, DIO mice  Peripheral vascular disease (PVD) in db/db mice, DIO mice  Diabetic muscle amyotrophy (myopathy) in db/db mice, DIO mice  Long term DIO induces a obesity-related glomerulopathy HFD induces mouse obesity at C57BL/6 male mice for 18 weeks (A&B) and 30 weeks (C&D).Glomerulus enlarges with partial Glomerular mesenchymal cell hyperplasia at 30weeks as compared with that at 18 weeks...
Cardiovascular diseases  Acute ischemia, ischemia reperfusion injury models Stroke models  Ischemic model (permanent MCAO) in rodents  Ischemic reperfusion model (transient MCAO) in rodents  Hemorrhagic model (CIH) in rodents  Rat MCAO model Brain infarct size at different MCAO condition Acute myocardial infarction (AMI) models  Permanent / transient AMI in rodents, rabbit and pig  AMI induced heart failure model in rodents and rabbit  Rat AMI model and assessment Myocardial infarct size at different acute ischemia conditionRabbit AMI model and the changes in the infarct size and ECG at ischemia and reperfusion pointsPig AMI model and the changes in the infarct size at day 5 of reperfusion...
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