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Nanjing KCI Biotech Inc. 
Address:699-18 XuanWu Avenue, Nanjing, Jiangsu, China
Phone:86-025-85560000-1588 Mail: info@kcibiotech.com; zhuangyongjie@kcibiotech.com;

Cardiovascular diseases

Acute ischemia, ischemia reperfusion injury models,Stroke models
Ischemic model (permanent MCAO) in rodent and NHP
Ischemic reperfusion model (transient MCAO) in rodent and NHP
Hemorrhagic model (CIH) in rodent and NHP
 
Acute myocardial infarction (AMI) models
Permanent / transient AMI in rodent and NHP
AMI induced heart failure model in rodent and NHP
 
Peripheral vascular disease (PVD)
Limb ischemia reperfusion models in rodent
 
Atherosclerosis models
Endothelial cell denudation induced intimal thickness model in rodent
HFD + cholesterol induced atherosclerosis model in hamster and rabbits
Blood flow induced intimal thickness model in rabbits
 
Abdominal aortic aneurysm model (AAA)
Collagenase induced AAA in rodent


Metabolic Diseases
Obesity
High fat diet (HFD)-induced obesity mice (DIO mice)
ob/ob mice, db/db mice
HFD induced DIO Rats
fa/fa rats
HFD induced Non human primate obesity (DIO monkey)
 
Diabetes
HFD (60% kcal)-induced DIO mice with diabetes
ob/ob, db/db Mice with diabetes
NHP diabetes including spontaneous diabetes in Rhesus and /or cynomolgus monkey (aged), and HFD-induced DIO monkeys with diabetes
 
Diabetic Complication
Diabetic nephropathy in db/db mice, DIO mice
Peripheral vascular disease (PVD) in db/db mice, DIO mice
Diabetic muscle amyotrophy (myopathy) in db/db mice, DIO mice
 
Dyslipidemia
High fat diet/ high cholesterol/ high fructose diet models in rodents, guinea pig, hamster, and monkey
 
Techniques
Readouts: Body weight, food intake, defecation, fat pad content, fasting plasma glucose, insulin, liver function, renal function, blood biochemistry, HbA1c, glucose tolerance test (OGTT, IPGTT), Insulin test (IT), histopathology
 
Liver Diseases
Acute liver injury models
Alcohol induced acute liver injury in Kunming mouse & non human primate (NHP)
CCl4 induced acute liver injury in rodents & NHP
Liver ischemia reperfusion injury model in rodent
 
Chronic fatty liver models
Obesity and liver damage models in rodent and NHP
 
Chronic liver injury models
CCl4 induced liver fibrosis (rodent)

CCl4 induced liver cirrhosis (rodent)

Bile duct ligation (BDL) induced liver fibrosis (rodent)

 

Non Alcoholic steatohepatitis (NASH) / HCC models
Fatty liver with NASH model
DIO + CCl4 induced NASH in rodent and NHP
NASH-HCC model in mice
 
Complicated factor induced chronic liver injury model
High fat diet+alcohol+CCl4 induced liver fibrosis model in rodent and NHP
 
Techniques
Clinical observation and physical examination
Body weight, behavior, food intake, water intake, defecation
Liver weight and spleen weight, ascite measurement, portal vein pressure
 
Biomarker analysis
Serum ALT / AST / TB analysis
Gene expression and profiling (RT-PCR, microarray gene expression, miRNA)
Protein and metabolite profiling (WB, ELISA, mass spectrometry)
Hepatic hydroxyproline content
 
Histopathology analysis
H&E staining
Sirius red and Masson Trchrome staining
Immunohistochemical staining

Kidney Diseases
Acute renal damage
Ischemic reperfusion injury models in rodent and NHP
Acute ureteral obstruction model in rodent and NHP
 
Subacute / chronic renal failure models
Sub-total (5/6) nephrectomy model rodent and NHP
Sub-total renal infarction (1k nephrectomy with 1k 2/3 infarction) model in rodent
Tubular toxic (adenine toxic) model
 
Nephropathy models
Obesity-related glomerulopathy
Diabetic nephropathy
 
Kidney transplantation models
Rat warm kidney graft transplant
Rat delayed kidney graft transplant
NHP kidney graft transplant
 
Inflammation and Autoimmune Diseases
LPS-induced acute lung inflammation in rats and mice
 
Experime,ntal allergic encephalomyelitis (EAE)
MBP induced acute EAE in Lewis rats
PLP139-151 induced EAE in SJL/J mice
MOG35-55 induced EAE in C57BL/6 mice and NHP
 
Lung Fibrosis
Bleomycin induced lung fibrosis in rodent
 
Rheumatoid Arthritis
Adjuvant induced arthritis (AIA) in rats
Collagen type II induced arthritis (CIA) in mice, rats and NHP
Spontaneous rheumatoid arthritis in NHP
 
Osteoarthritis (OA)
MIA induced OA in rats
Joint operation induced OA in NHP
 
Inflammatory Bowel Disease (IBD)
DSS induced colitis in C57BL/c mice
TNBS/DNBS induced colitis in rodent
Spontaneous IBD in NHP

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